Readily biodegradable but failing the 10-day window. [PubChem] Type Small Molecule Groups Experimental Structure BOD5*100/COD provides substance information on the substance’s BOD5*100/COD values displayed in O2 (milli)gram per gram test material. EC10 / LC10 or NOEC for freshwater sediment provides substance information on the substance’s effect concentration/lethal concentration for 10% of the model organisms feeding off the freshwater sediment or the no observed effect concentration for of the model organisms feeding off the freshwater sediment. This section summarises the values related to toxicity to (terrestrial) plants from all registered dossiers for the substance. Degradation rate constant with OH radicals provides substance information on the substance’s degradation rate constant with OH Radicals as a reaction type in cm3molecule-1s-1, cm3molecule-1d-1, m3molecule-1s-1 or m3molecule-1d-1. Note: Registrants can also select ‘other’ as the type of density. Different classifications can also be due to technical errors made during the notification process. This section provides environmental fate and pathways information compiled from all automatically processable data from REACH registration dossiers that is available to ECHA at the time of generation. This section summarises the values related to toxicity to aquatic plants (other than algae) from all registered dossiers for the substance. Note: Results without a concentration value are not processed for the Brief Profile. Data for workers – eye exposure provides information on the substance’s hazard assessment conclusions regarding eye exposure (for workers). If more than one IUPAC name is available from REACH registered dossiers, all IUPAC names are displayed in ‘Other names’ section of the Brief Profile. According to the classification provided by companies to ECHA in REACH registrations this substance causes serious eye irritation and may cause respiratory irritation. The information is aggregated from REACH registered dossiers provided by industry through a use descriptor system based on five separate descriptor lists which in combination with each other form a brief description of use and exposure for certain life cycle stage. If so, the data provided is not processed for the Brief Profile. 'IUPAC name' is the generic field by which substance names are provided in various data submission tools. The following properties have been highlighted as critical: The substance properties displayed in this section (with the exception of PBT properties) are derived from harmonised classification and labelling (CLH) and/or REACH registered dossier information. REACH registration dossiers have greater data requirements (support studies) than notifications under CLP. The availability of additional data beyond the five results displayed is indicated by (…). pH provides substance information on the substance’s acidity level measured in pH at a temperature measured in °C and a concentration measured in (milli)grams per litre. NACRES NA.22 H atm provides substance information on the substance’s Henry’s Law Constant in atm at temperature measured in °C and a pressure measured in Pascal. Since a two dimensional chemical structure can be drawn in various ways, there are several correct SMILES notations for one molecule. Learn More. EC10 / LC10 or NOEC for freshwater algae provides substance information on the substance’s effect concentration/lethal concentration for 10% of the tested freshwater algea or the no observed effect concentration for freshwater algae. LC50 for freshwater invertebrates provides substance information on the substance’s lethal concentration for 50% of the freshwater invertebrates in the test, displayed in milligram per litre. ABC corresponds to the atomic number of the most characteristic element or the most characteristic organic group in the molecule. Melting point, 105.5°C. Use descriptors were adapted from ECHA guidance to improve readability and may not correspond textually to descriptor codes description as in ECHA guidance chapter R.12: Use Descriptor system of ECHA Guidance on information requirements and chemical safety assessment. [. 2006 Oct;5(10):821-34. Melting / freezing point provides substance information on the melting/freezing point in °C at a pressure measured in Pa. Select which sections to print from the substance’s Brief Profile. The information has not been reviewed or verified by ECHA or any other authority. Additives are the constituents which have been intentionally added during the manufacturing process to stabilise the substance. ThOD provides substance information on the substance’s ThOD values displayed in O2 (milli)gram per gram test material. When more than one summary is provided, DN(M)EL values may refer to constituents of the substance and not to the substance as a whole. EC Inventory, C&L Inventory, Registration dossier, REACH pre-registration. Suspendisse porttitor leo quis purus porttitor posuere sit amet sit amet nunc. PNEC STP, data displayed in milligram per litre. Water solubility provides substance information on the substance’s solubility in water in grams per litre at a temperature measured in °C. This section summarises the values related to short term toxicity to aquatic invertebrates from all registered dossiers for the substance. Processable data is prioritised by the toxicity descriptor type (see list below) and subsequently further prioritised by duration (longer prioritised over shorter). Displayed are the RANGES of min – max of the PRIORITISED value(s) within the five highest priority groupings of provided data. Biocidal product authorisation – indicates if authorised biocidal products exist which use this substance as an active ingredient. This section summarises the values related to adsorption/desorption from all registered dossiers for the substance. Please see the registered dossiers for substance information for the following endpoints: The ’Substance identity’ section links substance identification information from all databases that are maintained by ECHA. Pow provides substance information on the partition coefficient type Pow at a temperature measured in °C and acidity in pH. It is a conjugate acid of a pimelate and a pimelate(1-). Long-term EC10 or LC10 or NOEC for mammals provides substance information on the substance’s effect concentration or lethal concentration (long term) for 10% of the mammals in the test, or the no observed effect concentration for mammals. Furthermore, updates in the source data may not always result in an update of the Brief Profile. For general information about any of the different regulations which currently fall under ECHA’s mandate please see the links below. Half-life in soil provides substance information on the substance’s half-life in water in seconds/minutes/hours/days/weeks/months/years at a temperature measured in °C. Beilstein/REAXYS Number 1210024 . Nat Rev Drug Discov. The chart displays the number of matching substance classifications (hazard class, categories and hazard statements) provided by manufacturers and importers under REACH and CLP notifications, as well as whether the substance is defined under harmonised classification and labelling (CLH). CAS names gives the name(s) provided to ECHA by the Chemical Abstracts Service, a division of the American Chemical Society, where available. The percentage is based on the count of values provided. PBT properties are derived from REACH registered substances dossiers. This section summarises the flash point values from all registered dossiers for the substance. Log Pow (Log Kow) provides substance information on the partition coefficient type Log Pow (Log Kow) at a temperature measured in °C. If you have any comments or suggestions, please contact ECHA using our contact form. DAP is often found in the peptide linkages of NAM-NAG chains that make up the cell wall of gram-negative … This section displays the values related to endocrine disrupter mammalian screening from all registered dossiers for the substance. It is formed upon oxidation of fats (hence its name, from Greek pimele, “fat”) and occurs in the urine of herbivores. Bioaccumulation Factor (aquatic species) L/kg ww provides substance information on the substance’s bioaccumulative properties for aquatic species measured in litre per kilogram  (wet weight). Processable data is prioritised by the toxicity descriptor type (see list below) and subsequently further prioritised by duration (longer prioritised over shorter). Displayed are the RANGES of min – max of the PRIORITISED value(s) within the five highest priority groupings of provided data. This section summarises the melting and freezing point values from all registered dossiers for the substance. This section summarises the dissociating values from all registered dossiers for the substance. Processable data is prioritised by the toxicity descriptor type (see list below) and subsequently further prioritised by duration (longer prioritised over shorter). Registrants can report substance information on viscosity as: Static viscosity at 20°C provides substance information on the substance’s (static) viscosity per square millimetre per second at a temperature of 20°C. EC50/LC50 for marine sediment provides substance information on the substance’s effect concentration or lethal concentration for 50% of the model organisms feeding off the marine sediment, generally displayed in milligrams per kilogram (dry weight). Data is generally displayed in milligrams per litre. H dimensionless volumetric basis provides substance information on the substance’s Henry’s Law Constant in dimensionless volumetric basis at a temperature measured in °C and a pressure measured in Pascal. Jawad H. Murib, John H. Kahn, "Process for the production of pimelic acid." Processable data for study results is prioritised by test species (see list below) and subsequently further prioritised by the dose descriptor. Thirdly the display of data is prioritised by units. H Pa m3/mol provides substance information on the substance’s Henry’s Law Constant in Pa m3/mol at a temperature measured in °C and the atmospheric pressure measured in Pascal. More about CAS and the CAS registry can be found here. Y is the check-digit calculated in accordance with the 10-digit ISBN method. U.S. Patent US4888443, issued April, 1970. EC10 / LC10 or NOEC for marine water invertebrates provides substance information on the substance’s effect concentration/lethal concentration for 10% of the tested marine water invertebrates or the no observed effect concentration for marine water invertebrates. Registrants can register their substance explosiveness as: Explosiveness. EC10 / LC10 or NOEC for marine fish provides substance information on the substance’s effect concentration/lethal concentration for 10% of the tested freshwater fish or the no observed effect concentration. Half-life in sediment provides substance information on the substance’s half-life in sediment in seconds/minutes/hours/days/weeks/months/years at a temperature measured in °C.Note: Results without a measurement condition (temperature) are not processed for the Brief Profile. After evaluation, proposals may be made for further regulatory action regarding the substance. disodium tetraborate EC no. EC10 / LC10 or NOEC for freshwater plants provides substance information on the substance’s effect concentration/lethal concentration for 10% of the tested freshwater plants or the no observed effect concentration for freshwater plants. IUPAC names gives all the non-confidential names provided to ECHA in submissions under REACH, CLP, BPR and PIC, where indicated to be a IUPAC name. For accuracy reasons, substance manufacturers and importers are responsible for consulting official sources. Hazard statements were adapted to improve readability and may not correspond textually to the hazard statements codes description in the European Union Specific Hazard Statements (EUH) or, The (√- check mark)-icon indicates the classification is defined under. Dissipation Half-life of parent compound provides substance information on the substance’s dissipation half-life for the parent compound per second/minute/hour/day/week/month/year. PNEC sediment, data displayed in milligram per kilo sediment (dry weight). Solubility in organic solvents / fat solubility. Data is generally displayed in milligrams per kilogram bodyweight per day.Prioritization by test species: See ‘Summary effect on fertility oral route’. Applicant’s summary and conclusion – Interpretation of results (dermal). If so, the data provided is not processed for the Brief Profile. there is no manual verification or assessment of the correctness of the data. If so, the data provided is not processed for the Brief Profile. Bioaccumulation Factor (terrestrial species) L/kg ww provides substance information on the substance’s terrestrial bioaccumulative properties measured in litre per kilogram (wet weight). Dynamic viscosity at 20°C provides substance information on the substance’s (dynamic) viscosity per millipascal second at a temperature of 20°C. The Agency thus cannot guarantee the correctness of the information displayed. This section summarises the values related to phototransformation in soil from all registered dossiers for the substance. The % is based on count of values provided. Note: Registrants can also select ‘other’ as the unit of measure for pressure. SMILES is the acronym for Simplified Molecular Input Line Entry Specification, a chemical notation system used to represent a molecular structure by a linear string of symbols. Articles of Pimelic acid are included as well. For temperature for example, data is standardised and displayed in Celsius (°C). Thirdly the display of data is prioritised by units. Displayed are the RANGES of min – max of the PRIORITISED value(s) within the five highest priority groupings of provided data. Displayed are the RANGES of min – max of the PRIORITISED value(s) within the five highest priority groupings of provided data. All the source data on which the summaries on this page are based, is provided by industry and stored in the ECHA databases. Close Find out more on how we use cookies. 2006 Dec;5(12):993-6. EC10 / LC10 or NOEC for marine water plants provides substance information on the substance’s effect concentration/lethal concentration for 10% of the tested marine water plants or the no observed effect concentration for marine water plants. Note: Registrants can also select ‘other’ as the type of Henry’s law constant. LC50 for marine water fish provides substance information on the substance’s lethal concentration for 50% of the marine water fish in the test, displayed in milligram per litre. EC/LC50 for freshwater sediment provides substance information on the substance’s effect concentration or lethal concentration for 50% of the model organisms feeding off the freshwater sediment,  generally displayed in milligrams per kilogram (dry weight). Note: Registrants can also select ‘BMD’, ‘BMC’, ‘dose level’ and ‘conc. Long-term EC10 or LC10 or NOEC for soil microorganisms provides substance information on the substance’s effect concentration or lethal concentration (long term) for 10% of the soil microorganisms in the test, or the no observed effect concentration for soil microorganisms. Other relevant information includes the following: To see the full list of notified classifications and have more information on impurities and additives relevant to classification, you can consult the C&L Inventory. Regulatory process names gives the names under which the substance appears in ECHA's regulatory processes and lists. Find manufacturers and suppliers for Pimelic acid, 111-16-0. Log Koc at 20°C provides substance information on the substance’s log Koc adsorption at a temperature 20 °C. level’ as the dose descriptor. Hazard for terrestrial organisms provides information on the substance’s hazard assessment conclusion related to terrestrial organisms/soil. Use this link for bookmarking this species for future reference. The Brief Profile is automatically generated; note that it does not currently distinguish between harmonised classification and minimum classification; information requirements under different legislative frameworks may therefore not be fully up to date or complete. Data is generally displayed in milligrams per kilogram in the case of soil (dry/wet weight), or gram per hectare. Its chemical formula is CH 3 (CH 2) 14 COOH, and its C:D is 16:0. Registrants can choose from the following picklist endpoint conclusions/effect levels: Respiratory irritation provides substance information on the substance’s irritation effect on the respiratory system. For substance’s physical state at 20°C and 1 013 hPa, registrants can classify their substance as: For substance’s form, registrants can classify their substance as: For substance’s odour, registrants can classify their substance as: For substance’s type, registrants can classify their substance as: Summary data is collected from the endpoint summary(ies) provided by registrants of REACH dossiers. Koc provides substance information on the substance’s Koc adsorption at a temperature measured in °C and a percentage of organic carbon. Each InChI string starts with the InChI version number followed by the main layer. Registrant can provide information on eye exposure as mentioned above for ‘Data for workers – eye exposure.’. See the official IUPAC website for more information on the International Union of Pure and Applied Chemistry. Short-term EC50 or LC50 for terrestrial plants provides substance information on the substance’s effect concentration or lethal concentration (short term) for 50% of the terrestrial plants in the test, generally displayed in milligram per kilo soil (dry weight). This section summarises the values related to endocrine disrupter testing in aquatic vertebrates from all registered dossiers for the substance. The EC name and number are the official identifiers for substances within the European Union and can be found in the EC Inventory. ECHA has no public registered data on the types of manufacture using this substance. For this endpoint registrants do not provide study result data. pKa at 20°C provides numerical substance information on the dissociation constant in pKa at a temperature of 20°C. If only waived data is available for the substance, following justifications for data-waiving can be displayed in the Brief Profile: Some endpoints are not included in the Brief Profile due to the use of free text and/or complex field(s) in the reporting of information, which cannot be easily summarised by an automatic algorithm. Notification – indicates that notified C&L’s have been submitted to ECHA for a substance. EC10 / LC10 or NOEC for freshwater fish provides substance information on the substance’s effect concentration/lethal concentration for 10% of the tested freshwater fish or the no observed effect concentration. Data is generally displayed in milligram per kilo bodyweight. Note: Registrants can also select ‘other’ as the unit of measure. Otherwise data is displayed reported as provided by the registrant(s).The availability of additional data beyond the five results displayed is indicated by (…). Linear Formula HO 2 C(CH 2) 5 CO 2 H . If there are additives and impurities relevant for the substance classification, these are also indicated. H atm m3/mol provides substance information on the substance’s Henry’s Law Constant in atm m3/mol at a temperature measured in °C and a pressure measured in Pascal. However, substance notifications in the Brief Profile are aggregated independently of the impurities and additives. Organic Acids Tricarboxylic Acids Common name Molecular formula Structural formula pKa Citric acid C6H8O7 pKa1 = 3.13 pKa2 = 4.76 Harmonised C&L– indicates if a European Union harmonised classifications and labelling has been assigned to the substance according to Annex VI to CLP and subsequent ATPs. The Agency does not take any responsibility whatsoever for any copyright or other infringements that may be caused by using the information. pimelic acid - cas 111-16-0, synthesis, structure, density, melting point, boiling point Skin sensitisation provides substance information on the substance’s sensitisation effect on the skin. Data is generally displayed in milligrams per kilogram in the case of soil (dry/wet weight), or gram per hectare. If so, the data provided is not processed for the Brief Profile. Diaminopimelic acid (DAP) is an amino acid, representing an epsilon-carboxy derivative of lysine.. DAP is a characteristic of certain cell walls of some bacteria. Registrants can identify the origin of their substance as being: If more than one type of substance is registered, both types will be displayed. Log Kd provides substance information on the substance’s Koc adsorption at a temperature measured in °C and a percentage of organic carbon. Please note: The icons in this section are only meant as visual indicators to help communicate information about the abovementioned critical properties. If so, the data provided is not processed for the Brief Profile. Displayed are the RANGES of min – max of values (provided in %). Data is generally displayed in milligrams per kilogram in the case of soil (dry/wet weight), or gram per hectare. If so, the data provided is not processed for the Brief Profile.Prioritization by test species: Processable data for the summary is prioritised by test species (see list below) and subsequently further prioritised by the dose descriptor. Displayed are the RANGES of min – max of the PRIORITISED value(s) within the five highest priority groupings of provided data. Registrants can provide data for one or more of the following picklist options: Note: Registrants can also select ‘other’ as the solvent. Registrants can identify their substance as being a mono-constituent substance, multi-constituent substance, UVCB, polymer or specify another type. Displayed are the RANGES of min – max of the PRIORITISED value(s) within the five highest priority groupings of provided data. Displayed are the RANGES of min – max of the PRIORITISED value(s) within the five highest priority groupings of provided data. It has a role as an Escherichia coli metabolite and a Daphnia magna metabolite. In most cases, impurities constitute less than 10% of the substance. This section summarises the values related to Henry’s law constant (H) from all registered dossiers for the substance. If so, the data provided is not processed for the Brief Profile. Otherwise data is displayed reported as provided by the registrant(s).The availability of additional data beyond the five results displayed is indicated by (…). If more than one numerical result is available per endpoint, the range of results (min–max) and range of experimental conditions will be presented (RANGE method). ECHA has no public registered data on the routes by which this substance is most likely to be released to the environment. The Index number for each substance is in the form of a digit sequence of the type ABC-RST-VW-Y. If more than one value is found for this section, the range of min-max values will be displayed here. If such information is available in ECHA’s database and is it not claimed confidential, the molecular formula and molecular structure will be displayed here. Molecular structure displayed in this section is based on InChI annotation from IUCLID reference substances database and stored in the ECHA database. See information under ‘Study results oral’. Values are generally displayed in milligram per kilo food. EC50/LC50 for marine water plants provides substance information on the substance’s effect concentration or lethal concentration for 50% of the marine water algae in the test, generally displayed in milligram per litre. Inhalation exposure provides information on the substance’s hazard assessment conclusions regarding inhalation exposure. The Brief Profile is produced based on data in ECHA’s databases and maintained by the Agency, and therefore the Brief Profile as a dissemination tool falls under ECHA’s responsibility. For accuracy reasons, substance manufacturers and imports have the responsibility to consult official sources, e.g. Please see Registrants/Suppliers details. 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase, GC-MS Spectrum - GC-EI-TOF (Pegasus III TOF-MS system, Leco; GC 6890, Agilent Technologies), splash10-056s-1910000000-58bf29a41b2e4b405df9, splash10-0r7l-9100000000-aeff5d9828ac92b33028, splash10-054k-1910000000-fc6cb63b081b4f5f7fd3, splash10-054k-1900000000-403538c5b4091abf0a3d, MS/MS Spectrum - Quattro_QQQ 10V, Negative, splash10-0002-9300000000-a3d2b3924fcede41e331, MS/MS Spectrum - Quattro_QQQ 25V, Negative, splash10-0002-9100000000-7050dc1518d598ad5051, MS/MS Spectrum - Quattro_QQQ 40V, Negative, splash10-052e-9200000000-84550d0cfeb05e8d79bd, MS/MS Spectrum - EI-B (Unknown) , Positive, splash10-0r7l-9100000000-b698134a5d1e523a961e, LC-MS/MS Spectrum - LC-ESI-QQ (API3000, Applied Biosystems) 10V, Negative, splash10-0a4i-0900000000-a3b877a40a98e4d07993, LC-MS/MS Spectrum - LC-ESI-QQ (API3000, Applied Biosystems) 20V, Negative, splash10-0002-9500000000-6f90176eaadac29eae28, LC-MS/MS Spectrum - LC-ESI-QQ (API3000, Applied Biosystems) 30V, Negative, splash10-0002-9000000000-859f1028218d04c20dc6, LC-MS/MS Spectrum - LC-ESI-QQ (API3000, Applied Biosystems) 40V, Negative, splash10-0002-9000000000-ef436118494b323530f4, LC-MS/MS Spectrum - LC-ESI-QQ (API3000, Applied Biosystems) 50V, Negative, splash10-0002-9000000000-15fa4059d8c10e1e3a03, Predicted MS/MS Spectrum - 10V, Positive (Annotated), Predicted MS/MS Spectrum - 20V, Positive (Annotated), Predicted MS/MS Spectrum - 40V, Positive (Annotated), Predicted MS/MS Spectrum - 10V, Negative (Annotated), Predicted MS/MS Spectrum - 20V, Negative (Annotated), Predicted MS/MS Spectrum - 40V, Negative (Annotated), splash10-0002-9000000000-0ece97699a3ecbbd29c5, splash10-0002-9000000000-aa9d7a3b0b034eb999ac, Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Aliquam nec erat semper, suscipit libero et, bibendum mauris. Registrants can choose from the following picklist endpoint conclusions/effect levels: Eye irritation provides substance information on the substance’s irritation effect on the eye. Water solubility provides substance information on the substance’s solubility in water in grams per litre at a temperature measured in °C. This section summarises the values related to phototransformation in water from all registered dossiers for the substance. Harmonisation is based on the substance’s physical, toxicological and eco-toxicological hazard assessment. Nulla pulvinar vitae nunc vitae sagittis. EC10 / LC10 or NOEC for freshwater invertebrates provides substance information on the substance’s effect concentration/lethal concentration for 10% of the tested freshwater invertebrates or the no observed effect concentration for freshwater invertebrates. Pimelic acid is the organic compound with the formula HO2C(CH2)5CO2H. the minimum numerical value associated with the highest priority picklist item. The IUPAC nomenclature is a systematic way of naming chemical substances, both organic and inorganic. EC50/LC50 for microorganisms provides substance information on the substance’s effect concentration or lethal concentration for 50% of the microorganisms in the test, generally displayed in milligram per litre. A group of compounds that are derivatives of heptanedioic acid with the general formula R-C7H11O4. Tap density provides substance information on the bulk density per grams per millilitre at a temperature measured in °C. There is additional data available for commercial users including Adverse Effects, Contraindications, and Blackbox Warnings. Displayed are the RANGES of min – max of the PRIORITISED value(s) within the five highest priority groupings of provided data. the electronic edition of the Official Journal of the European Union.This Brief Profile is covered by the ECHA Legal Notice. Applicant’s summary and conclusion – Interpretation of results. Tends to sublime. Drug created on June 13, 2005 07:24 / Updated on June 12, 2020 10:52. Short-term EC50 or LC50 for mammals provides substance information on the substance’s effect concentration or lethal concentration (short term) for 50% of mammals in the test, generally displayed in milligram per kilo food. Duis pulvinar non magna ac viverra.